is part of the antioxidant glutathione peroxidase Enzyme Systems Study on antioxidant effect of

Funding This work was supported by grants from the National Natural Science Foundation of China (31460613 and 31560649) and National Key Research and Development Program of China (2016YFD0500507 and 2018YFD0501600)

[DOI] [PubMed] [Google Scholar] 118.Donovan J.L., Chavin K.D., Devane C.L., Taylor R.M., Wang J.S., Ruan Y., Markowitz J.S

However, it should be noted that certain compartments, such as the endoplasmic reticulum, are maintained in an oxidized state (Hwang et al., 1992

Journal of Autoimmunity, 122 , 102666.

Deoxycholic acid (DCA), a secondary BA, inhibits the plasma membrane Ca + ATPase (PMCA), suppressing Ca + -NFAT2 signaling and reducing cytotoxic molecules such as IFN-, TNF-, and granzyme B (GzmB), potentially impairing ICI efficacy when intratumoral DCA is high (64, 67)

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