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Oligomycin, FCCP, rotenone + antimycin A (R/A) (Agilent, 103015-100) and etomoxir (Cayman Chemical Company, 11969) were used at final concentrations of 2.5 M, 1 M, 0.5 M, and 20 M, respectively

Dawn Ericsson, MD

4 In vivo models of pLGG 4.1 Generating non-NF1 pLGG xenograft models for preclinical drug testing One of the ultimate goals for developing pLGG mouse models is for preclinical drug testing

According to a 2023 cost analysis published in the Journal of Managed Care & Specialty Pharmacy, the average annual expense for VMAT2 inhibitors in the US exceeds US$ 90,000

doi: 10.1126/sciadv.abg4302 35 Villalpando-RodriguezGEBlanksteinARKonzelmanCGibsonSB

In addition, the activation of the mTOR signaling pathway correlates with an inhibition of the autophagic process, favoring the proliferation and pluripotency of glioma stem cells [121]