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Reasons for Excessive prescription a survey of the prescribing habits of a 2000 random sample of general practitioners in England and Wales in 1967 showed that 33% of all prescriptions for cyanocobalamin and hydroxocobalamin in 1967 were for conditions other than pernicious anaemia and other hypochromic anaemias Discussion We are very conscious of the imperfections of our data ..We are also aware in retrospect that 1966 was not a good year to choose as it was a period of change in ideas about the correct dosage of B12 for pernicious anaemia we still however believe our exercise to have been worthwhile as it has shown how substantial financial saving could be made at no cost to health and a considerable saving of inconvenience to patients , doctors, and nurses

This condition, defined as periorbital hyperpigmentation, is more noticeable, especially in individuals with light skin tone

doi: 10.1080/10245332.2017.1318334

MOTS-c handles cellular energy regulation, metabolic flexibility, and mitochondrial signaling

J Inflamm (Lond)