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From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)

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It facilitates glymphatic clearance, a convective exchange of CSF and interstitial fluid (ISF) that removes metabolic waste, but also A and tau [359, 366]

Although its primary use is often associated with supporting healthy growth hormone (GH) levels, many people explore it for its potential in aiding muscle

Furthermore, obesity and metabolic syndrome (MetS) also appear to be risk factors for the occurrence of PD through the same mechanism, namely systemic inflammation, insulin and leptin resistance, blood-brain barrier disruption, and altered brain metabolism (Neto et al., 2023

Some of the arm irritation also comes from the muscle reacting to the small amount of vaccine liquid that was injected into the arm