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In clinical advancement, strategies with more realistic value include local delivery or use as adjuvant therapy, rather than relying on long-term systemic exposure

Each member of the treatment groups received an icv injection of scopolamine hydrobromide (70 nmol in 2 aCSF over a duration of 20 s) 20 min prior to testing followed by Nle'-AnglV or one of the analogs (in 2 aCSF) 5 min prior to testing

Typical HCG dosages used with TRT include: 500-1500 IU per week total Divided into 2-3 doses per week Common protocols: 500 IU 2-3x/week or 250 IU every other day The optimal dose varies by individual and should be determined by a doctor based on labs and symptoms

Intracellular reactive oxygen species levels were measured to assess oxidative stress among three groups of MII oocytes

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Funding The authors would like to thank Shahid Beheshti University of Medical Sciences for financial support (IR.SBMU.PHNS.REC.1404.051)