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Yeast two-hybrid assay The Matchmaker Two-Hybrid System and CNMT gene, cloned into the bait Gal4-BD vector pGBKT7 were used for the yeast two-hybrid assay as described

10.1016/j.psychres.2021.114317 48 GeC.WangS.WuX.LeiL

A study comparing GSH, GSSG, GPx and GR levels in the caudate region of the brain after death in schizophrenia patients and normal subjects showed that the schizophrenia group had significantly lower levels of GSH, GPx, and GR than the control group, which did not have any psychiatric disorders (24).The potential mechanism by which the reduced level of GSH affects the morphology of neurons may be through oxidative stress damage inducing lipid peroxidation, the protein denaturation, which further leads to cell membrane alterations and cytoskeletal changes, affecting the normal functioning of neuronal cells in the corresponding brain regions involved in schizophrenia (25)

C Protein levels of ASS1 and PYCR1 in KYSE150 cells transfected with siRNA-Control or siRNA-NRF2 (left) /-ATF4 (right)

This group has the typical structure within the plane of the 3-hydroxyflavone base

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