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Description
In this line, GSH depletion in glial cells, including astrocytes, leads to neuroinflammatory phenotype ( 2+ -dependent glutamate release from microglial cells is observed upon hypoxia-mediated redox imbalance likely via the activation of IP 3 R which could participate in excitotoxic damages during brain insults ( 2+ homeostasis and thus result in unregulated Ca 2+ -dependent release of factors as proinflammatory cytokines or glutamate endangering neuronal cell survival

De Cecco, M

2023 Feb 28;24(5):4707

"How Kris Aquino's son Josh celebrated 26th b-day"
Wani et al

Nature 413, 171174
