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Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1

doi: 10.1200/JCO.2010.32.1877 12 HoASKimSTighiouartMGudinoCMitaAScherKSet al

About 95% of BA are reabsorbed in the ileum and returns to the liver via sodium taurocholate co-transporting polypeptide (NTCP) and organic anion transport polypeptides (OATPs) mediated BA reuptake from the portal venous circulation [10,11,12])

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Most cargoes included a variety of goods to minimize this problem

References Therapeutic Goods Administration
