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Studies have shown that colorectal cancer liver metastasis (CRLM) PDOs can highly preserve the histopathological and molecular characteristics of primary tumors while successfully capturing intra- and inter-patient heterogeneity [180]

The testes contain an abundance of GSH-dependent dehydroascorbate reductase, which keeps vitamin C itself in a reduced condition [171, 172]

When oxidized,, reduced glutathione converts to oxidized glutathione.Oxidative stress can also lead to reversible S-glutathionylation modification of proteins

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After iv administration, the entire dose of the drug is immediately available for metabolism and excretion