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In local synovial tissues, the hypoxic environment favors stable expression of HIF-1, enhancing the survival of pathogenic CD4 + T cell and further aggravating inflammation (141, 151)

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Komaki R, Putnam JB, Roth JA, Allen P, Swisher S, Walsh G, Kies M, Fossella FV, Hong WK, Herbst R, Oh YW, Liao Z, Vaporciyan A, Rice D, Smythe R, Munden R, Cox JD

These nutrients clear out the toxins from our fat cells and prepare them for elimination in Phase II

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