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Description

Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

5-Amino-1MQ is a small molecule membrane-permeable inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT)

A small molecule inhibitor of nicotinamide N-methyltransferase for the treatment of metabolic disorders

Recent breakthrough research in 2024 demonstrated that 5-amino-1MQ combined with exercise training in aged murine models produced enhanced adaptations compared to exercise alone, with grip strength improvements of approximately 60% and alterations in daily locomotor activity patterns with modified recovery kinetics

Current research priorities include large-scale studies to better understand the tissue-specific effects of NNMT inhibition and the temporal dynamics of metabolic reprogramming following treatment