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First of all, the study population was mainly from Iran, and the number of participants was small, so it needs to be further verified by increasing the sample size in future studies

They found that none of the patients with mild MR progressed to severe MR, whereas 50% with moderate MR progressed to severe MR

[DOI] [PMC free article] [PubMed] [Google Scholar] 497.Esposito, K

A total of at least 10,000 cells was counted

The main limitations of that study included the small sample size, open-label design, and absence of concomitant rifaximin use, which is known to reduce short-term mortality