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278 The mice administered intraperitoneally with 50 mg/kg body weight dichloromethane/methanol leaf extract had reduced micronuclei formation in an irradiation dose-dependent manner in the cytokinesis-blocked cultured splenocytes extracted from irradiated mice exposed to 0, 0.5, 1, 2, 3, and 4 Gy whole-body -radiation

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On the other hand, elevation of GSH levels enhance the antioxidant capacity of the cell and the resistance to oxidative stress, which may mediate treatment failure in cancer [100]

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106 Interestingly, targeting the Nrf2 pathway to overcome drug resistance in liver cancer involves the induction of excessive ROS