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The positions of water were primarily refined in Coot based on the receptor focused maps and further inspected with the density in the consensus maps

Among other things, they wrote, this could lead to confirmation bias

This inhibitory action was attributed to Norleual-AngIVs capacity to prevent HGF dimerization, a crucial step for c-Met activation, while Dihexa was subsequently confirmed to act as an agonist within this system

I added this out of interest

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