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These combination approaches aim to enhance tumor immunogenicity through targeted RCD induction, overcome immune evasion mechanisms, and improve the depth and durability of antitumor responses ( 5.1 pharmacological inducers combined with immune checkpoint inhibitors The combination of pharmacological inducers of regulated cell death (RCD), particularly ferroptosis inducers such as RSL3, Erastin, and GPX4 inhibitors, with immune checkpoint inhibitors (ICIs) like anti-PD-1 antibodies, has demonstrated promising synergistic antitumor effects in preclinical melanoma models (126)

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It is plausible that DHAHLA may present beneficial anti-inflammatory effects in both human and murine white adipose tissue, as has already been discovered for other DHA products [270]

Suaid CA, Santos AP, Yamane F de O, Fazan VPS, Barreira AA (2016) Aspects of the macro and microscopic anatomy of the sciatic nerve in wistar rats

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