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10.3389/fmed.2022.801632 58 KurataT.TamuraK.KanedaH.NogamiT.UejimaH.Asai GoG.et al (2004)

Additional conjugation with lipoproteins, leveraging lipophilic interactions with tocopherol, further improved delivery to neurons and glial cells via lipoprotein receptormediated endocytosis

Most of the data come from animal studies or small, open label reports

Amyloid beta-based therapy for Alzheimers disease: challenges, successes and future

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But the low quality of information available back then made it very easy to make a dosing mistake, especially if intrinsic factor saturation and passive absorption are not understood