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The importance of Nrf2 function is shown in an animal model in which the upregulation of Nrf2 will protect against dietary carcinogen diethylnitrosamine (DENA)-induced liver carcinogenesis [51]

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Tesamorelin received FDA approval in 2010 as Egrifta for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy , a metabolic complication of antiretroviral therapy characterised by preferential accumulation of visceral adipose tissue and associated cardiovascular and metabolic risk