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Many papers implicate mGluR5 as a major activator of astrocyte Ca 2+ (Bezzi et al., 1998

Impact of mind-body intervention on proinflammatory cytokines interleukin 6 and 1: a three-arm randomized controlled trial for persons with sleep disturbance and depression

The animal evidence is consistent with the mechanistic findings

1265 (Wiley, Hoboken, New Jersey, 2005)

Halstead SB, Shotwell H, Casals J (1973) Studies on the pathogenesis of dengue infection in monkeys

Without intentional high-protein meals, you lose lean muscle mass alongside fat which slows metabolism, changes body composition, and makes it harder to maintain results long-term
