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Multiplex assessment of protein variant abundance by massively parallel sequencing

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Increases in the expression of various molecules that have been noted in reactive astrocytes across multiple contexts include GFAP, vimentin, nestin (probably labelling proliferating astrocytes), synemin plectin, -crystallin B chain, monoaminoxodase-B (MAO-B), heat shock factor binding protein 1, complement C3, lipocalin 2, C-X-C motif chemokine ligand 10, SerpinA3N, LCN2 and others, 20,95,96,97,98,99,100,101,102,103 but it important to note that no single molecular marker (including GFAP) is an absolute, required and sufficient, indicator of astrocyte reactivity, and no molecular markers have yet been identified that reliably distinguish amongst different reactive astrocyte phenotypes

Biol Pharm Bull 39(2):199206 Shen C, Li Q, Zhang YC, Ma G, Feng Y, Zhu Q et al (2010) Advanced glycation endproducts increase EPC apoptosis and decrease nitric oxide release via MAPK pathways

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