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Description
Iron-sensitive prodrugs that trigger active ferroptosis in drug-tolerant pancreatic cancer cells
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-KG can also be exported to the cytosol to be carboxylated into citrate through isocitrate dehydrogenase 1 (IDH1) and further into acetyl-CoA for de novo fatty acid synthesis (Fendt et al., 2004

These mechanisms elucidate the pathological underpinnings of ferroptosis across a spectrum of diseases and suggest potential therapeutic targets

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Kecel-Gunduza, S., Kocb, E., Bicaka, B., Kokcub, Y., Ozela, A
