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Questo meccanismo d'azione porta a una maggiore resistenza fisica e a una riduzione dell'affaticamento muscolare durante l'attivit

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Matsumoto M., Shannon Weickert C., Akil M., Lipska B.K., Hyde T.M., Herman M.M., Kleinman J.E., Weinberger D.R

(2008) 294:E8896

Disease-related targets were derived from the Genecards, OMIM, TTD and DisGeNET disease databases

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When HeLa cells are treated with Ero1 inhibitor (EN460), ER oxidative protein folding is impaired, reducing H 2 O 2 signaling and inhibiting Nrf2 translocation to the nucleus, resulting in a decrease in GPX8, resulting in increased ER calcium content and signaling (Granatiero et al., 2019)