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doi: 10.1038/s41467-021-27414-1 21 UrsiniFMaiorinoMValenteMFerriLGregolinC

A mere handful of drugs have been successfully developed and/or entered into clinical trials

Gonzalez-Burgos G

, 8 found lower activities of CuZn-SOD, GPx and CAT in the renal medulla, lower levels of CuZn-SOD, GPx but higher activity of CAT in the renal cortex, whereas Mn-SOD activity was increased in both the cortex and medulla of stroke-prone SHR when compared with age-matched 32-week-old WKY rats

MOTS-c (10 mg) is a mitochondria-derived peptide that activates AMPK, regulates nuclear gene expression under metabolic stress, and enhances insulin sensitivity [4][5][6]

354 Given these factors, targeting ferroptosis could be a potential strategy for the prevention and treatment of RA