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It influences cellular polarization, ionic currents across the cell membrane, gene expression, and the release of growth-promoting molecules 30

We hypothesize that excessive intake of folic acid depletes serum holotranscobalamin (holoTC), thereby decreasing active vitamin B-12 in the circulation and limiting its availability for tissues
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doi: 10.1002/14651858.CD006634.pub3 391 ZhangXFGuanXXTangYJSunJFWangXKWangWDet al

The research protocols used in animal studies provide starting points but require careful scaling and clinical validation

& Lavau, C