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If a clinically significant hypersensitivity reaction occurs, institute appropriate therapy and discontinue DUPIXENT
2.2.4 Collagen assembly and fibrogenesis: the key role of HSP47 HSP47 (Serpin H1) is indispensable for the efficient secretion, processing, fibril assembly, and deposition of collagen in the ECM
Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis

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Amstad P, Peskin A, Shah G, Mirault ME, Moret R, Zbinden I, et al
