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In certain embodiments antibody-drug conjugates (ADCs) are provided that comprise an anti-ALPP/ALPPL2 antibody attached to a cytotoxic/cytostatic drug, for example a drug that has activity against both dividing and resting tumor cells, such as DNA chelating agents

doi: 10.1021/acs.analchem.5b01556 176 XieGZhangSZhengXJiaW

Despite these challenges, an interlaboratory analysis using a harmonized LC-MS-based protocol for 133 oxylipins was able to achieve low technical variability

doi: 10.1016/j.intimp.2024.113828 93 ZengCLinJZhangKOuHShenKLiuQet al

Vitamin B12 supplementation is carried out until the deficiency is remedied, and if the factor causing the deficiency is not removed, continuous cobalamin supplementation is necessary

115 116 Mechanistically, alcohol-induced CYP2E1 overexpression enhances HBV replication by upregulating hepatocyte nuclear factor-4, the key transcription factor for the HBV core promoter, 117 and increases HCV-related mitochondrial ROS, reducing antioxidant capacity and depleting mitochondrial glutathione, which heightens oxidative damage and cell death