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Dyshomeostasis of cholesterol is one of the hallmarks of cancer 1

Therefore, any disruption of the microbiome in CKD can lead to intestinal barrier disruption and result in mucosal immune dysregulation, systemic immunological imbalance, and chronic inflammation, which lead to the progression of renal fibrosis, and the restoration of intestinal dysbiosis may improve this condition [124]

on the other, it can intensify oxidative stress by altering metabolic pathways (121)

The degeneration of SGN nerve fibers and synapses in cochlear explants following sevoflurane exposure was attenuated by 20(S)-Ginsenoside Rh1

Moreover, both 4-HNE immunoblot and immunostaining showed a significant increase in 4-HNE level in the APP Swe/Ind -overexpressing cells treated with BSO, further validating increased lipid peroxidation (Figure 2E-2G, Supplementary Figure 1)