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More recently, the effect of incorporating rigid linkers containing cyclic structures has been studied, as this results in PROTACs that are not only more potent, but also more stable

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[DOI] [PubMed] [Google Scholar] 32.Kumar S., Trivedi P.K

Zhang J, Sun X, Wang L, Wong YK, Lee YM, Zhou C

26 The compound has been available in clinical practice for several decades to treat various medical conditions, including bronchitis, acute respiratory distress syndrome, paracetamol intoxication, chemotherapy-related toxicity, doxorubicin cardiotoxicity, heavy metal intoxication, ischemia-reperfusion cardiac injury, human immunodeficiency virus infection or acquired immunodeficiency syndrome, and neuropsychiatric disorders