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Five years later (in 2008), the importance of ferrous iron, the system xc - (xCT) controlled cystine/cysteine redox cycle, and the glutathione peroxidase 4 (GPX4)-glutathione (GSH) redox system in lipid peroxidation and non-apoptotic cell death was highlighted by different research groups[10-12]

This highlights its crucial regulatory role in maintaining cartilage homeostasis