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Klink PR, Frable RA, Bornstein M

PMC 10506345

In general, the Prdx1 subfamily enzymes are the most highly expressed, making up 0.11% of the soluble protein in the cell

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Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

10.1093/aje/kww177 Am