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In vitro studies suggest that trimethoprim is a substrate of P-glycoprotein, OCT1 and OCT2, and that sulfamethoxazole is not a substrate of P-glycoprotein

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Introduction S-adenosylmethionine (SAMe) is a simple molecule, present in all living cells and synthesized in just one step by the coupling of L-methionine with the adenosyl moiety of adenosine triphosphate (ATP) [1,2]

This means they should be compared cautiously

Platinum-induced neurotoxicity and preventive strategies: past, present, and future