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et al., 2009), while IL-17 promotes BMSC proliferation, migration, and osteogenic differentiation through a process involving ROS and the p38/ERK-MAPK signaling pathway (Huang H

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The low CSF-to-plasma ratio of compound D and the absence of compound Q in CSF may suggest the need for Phase Ib dosing studies to explore novel strategies for increasing Q bioavailability and D levels in the CNS

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Davidson DG, Eastham WN

This occurs through sulfation, glucuronidation, and glutathione conjugation of toxins

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