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It was documented that NNMT overexpression in 769-P cells resulted in a decrease in overall histone H3 methylation while silencing NNMT in SKOV3 cells caused an increase in overall histone H3 methylation [54]

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During normal physiological conditions, the NAD + biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) (FIG

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