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Future studies need to focus more on validating the inductive effect of TMAO on ferroptosis in the in vivo OA models and human chondrocytes

The research revealed improved mitochondrial function and enhanced ATP production efficiency, contributing to overall energy levels and cellular vitality

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Despite these strategies, mucoadhesive particles predominantly adhere to the superficial mucus layer and, at least in the upper airways where mucus turnover is rapid with proper hydration (~1020 min) 144,145 , they are quickly cleared

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