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6.1 Other chain-breaking ATs Probucol was primarily designed and approved for medicinal use as a cholesterol-lowering agent in the treatment of coronary artery disease, and secondarily, it may provide antioxidant activity

plantarum ZLP001 could protected IPEC-J2 cells against H 2 O 2 -induced oxidative damage as indicated by cell viability assays and significantly alleviated apoptosis elicited by H 2 O 2 (Wang et al., 2021)

demonstrated that the secretion of apolipoprotein B-100, a protein needed to be folded oxidatively in the ER, was reduced in HepG2 cells cultured in riboflavin deficient medium 45
Recent evidence has indicated a lysosomalmitochondrial cross-talk that regulates APAP hepatotoxicity

Since the redox energy supply of NAD + is vital to glycolysis and the TCA cycle, forming NADH in the mitochondria, as well as a precursor in the de novo biosynthesis of guanosine monophosphate (GMP), we evaluated nicotinamide as a precursor of NAD + [30] to boost the production of GTP

It mitigates myeloperoxidase (MPO)-mediated oxidative stress and inhibits ferroptotic cell death in neurons, while also enhancing glutathione peroxidase 4 (GPX4) activity [74, 75]
