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PMID: 34628723 Turk J Biochem2025 Dec 23

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Impaired insulin signaling, diminished mitochondrial oxidative capacity, lipid peroxidation, ferroptosis, and microbial dysbiosis not only exacerbate hepatic steatosis but also facilitate the progression from simple steatosis to more severe forms of the disease, such as NASH and cirrhosis [51,56,63,64,65,66,67]

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We first assessed the impact of giredestrant and a sub-saturating (200 nM) concentration of palbociclib, intended to model the clinical scenario, as single agents and in combination, on the lipid profile of both MCF-7 and T47D cells 7 days after treatment