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2020;9:e58567

When your cells literally lack the molecular shuttles required to produce basic energy, the profound fatigue you experience is not a lack of willpower, motivation, or fitnessit is a very real, measurable physiological deficit

Although the results are not from a controlled study, and may self-select for patients who had benefit from the supplement, respondents reported improvements in pain, urethral burning, and urinary urgency/frequency

Methylmalonic and propionic aciduria

10.1152/ajpendo.00308.2010 206 ZhangS

Stephens FB, Marimuthu K, Cheng Y, Patel N, Constantin D, Simpson EJ, Greenhaff PL
