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In addition, moDCs have limitations with their generation time and limited functionality

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This model is based on the hypothesis that the transition of DNA methylation state of a CpG over a single cell cycle happens in three steps: 1) DNA is passively demethylated through replication, 2) DNA methylation transitions are mediated by TETs and DNMTs, and 3) DNA methylation transition combination states are merged from both homologous chromosomes

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