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These substitutions protect against dipeptidyl peptidase-IV (DPP-IV) cleavage, the enzyme that destroys natural GHRH within minutes (Alba et al., J Med Chem 2006)

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A., St George-Hyslop P., Westaway D., In Vivo Reduction of Amyloid-Beta by a Mutant Copper Transporter, Proc

It is a gentle, supportive approach to histamine clearance