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With the patch this problem is solved

Piccoli et al., 2008)
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CYP1A2 is responsible for the process of demethylating caffeine, resulting in the production of the main metabolites [62] paraxanthine (1,7-dimethylxanthine, around 84%), theobromine (3,7-dimethylxanthine, 12%), and theophylline (1,3-dimethylxanthine, 4%)

Psychiatry 61 , 925927 (2007)
