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If the thyroid acts to maintain constant basal levels of THs and subsequently keep the metabolic setpoint of cells unaltered, low TH concentrations trigger the release of thyrotropin-releasing hormone (TRH) from the hypothalamus, which stimulates the secretion of thyroid-stimulating hormone (TSH) in the anterior pituitary, which in turn induces the synthesis of T3 and T4 in the thyroid gland [33,34]

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