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Recent animal studies also demonstrated an increase of low-affinity bound copper in the CNS associated with enhanced oxidative stress following initiation of D-penicillamine therapy in the toxic milk mouse model

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Hargrove ME, Wang J, Ting CC

Figure 1 2.2.2 Attenuation of inflammatory response Neuroinflammation is a key pathological mechanism in neurodegenerative diseases and has been strongly implicated in PD

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Lastly, the synthetic mimics of seleno-GPxs appear to be an interesting strategy to develop radiation countermeasures