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[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Parker K.J., Oztan O., Libove R.A., Mohsin N., Karhson D.S., Sumiyoshi R.D., Summers J.E., Hinman K.E., Motonaga K.S., Phillips J.M., et al

doi: 10.1182/blood.2021012811 90 SaltarellaIMorabitoFGiulianiNTerragnaCOmedPPalumboAet al

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DCA has been described as an allosteric PDK inhibitor that, at mM concentration (IC50) and in concomitance with ADP, binds to the pyruvate pocket of the PDK complex enzyme, avoiding attachment of the kinase domain to the E2 domain 55,56