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[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA

Introduction Iron is an essential trace element that plays a crucial role in oxygen transport, oxidative phosphorylation, and the production of reactive oxygen species (ROS) ( Hamp gene encoding a suppressor of iron uptake, hepcidin ( Hfe gene are the most prevalent, constituting approximately 90% of adult hemochromatosis phenotypes in white populations of European descent ( Hjv ( Hfe2 ) gene are considerably less frequent but lead to juvenile hemochromatosis with a high degree of iron overload and overt cardiac phenotype ( Another route for improving chelation therapy is to combine iron chelators with L-type Ca 2+ channel blockers

Its weighing whether the substance can be consistently characterized, whether there are safety concerns (including impurities and immunogenicity), and whether the proposed uses have any credible evidence behind them