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Some miRNAs were designed to target 3-UTR of HER2 to inhibit HER2 protein expression [235]

10.3389/fnins.2018.00632 277 LiuL.WangL.XiaoY.LiuY.MengX.ShenX

In that study, UA activated microglia and upregulated autophagy-related proteins such as the LC3II/I ratio, Beclin-1, and LAMP1 in the hippocampus of AD model mice

[28] This symmetry of active site results in the different binding mode of the enzyme: It can bind with two dihydrofolate (DHF) molecules with positive cooperativity or two NADPH molecules with negative cooperativity, or one substrate plus one, but only the latter one has the catalytical activity
