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SCFAs can influence metabolic homeostasis by stimulating intestinal histohormones (e.g., GLP-1 and peptide YY) and by acting directly on enterocytes, adipocytes, immunocytes, and pancreatic -cells through GPCRs, including GPR41 (FFAR3), GPR43 (FFAR2), and GPR109A (HCA2) [780,781,782]

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Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders

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In this process, exercise-induced lactate accumulation can trigger the lactate clock, promoting the transition of microglia to a reparative phenotype [47]

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