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Glutathione

These disruptions include a reduction in SCFA producers and an increase in bacteria associated with inflammation and metabolic endotoxemia, which may serve as potential biomarkers for disease progression and severity

A prospective observational study revealed that treatment with AST-120 for 24 weeks in CKD patients significantly decreased serum IS levels, and concurrently increased GSH to GSSG ratios, suggesting that AST-120 potentially has a direct effect on relieving oxidative stress in these patients [78]

Gut surgery, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders are considered additional risk factors