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Ubiquitous proton pump inhibitor use has recently been linked to the development of gastric NENs through the trophic effect of gastrin on gastrin receptor-expressing enterochromaffin-like cells (1, 2)

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(C) Cells given 0.4 mM palmitic acid were treated with 100 nM Ex-4 in the absence or presence of 10 mM nicotinamide (NAM) or 10 M compound C (CC) for 24 hours

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Finally, consider whether the GLP-1 dose needs adjustment, as medication effectiveness can decrease over time

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doi: 10.2174/1570159X20666220420122322

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