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Moreover, ROS produced during CYP2E1-mediated ethanol metabolism would likely be particularly harmful because the fetal brain shows only low levels of antioxidant enzyme activity compared with adult brain (Henderson et al

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1013 These compounds are primarily derived from the diet and all contain a trimethylamine group

DNA methylation Genomic DNA was isolated from the liver tissue or cultured cells using an AllPrep DNA/RNA/Protein Mini Kit (Qiagen, Germantown, MD) following the manufacturers instructions

KATs can be classified into three families: the p300/CBP, the MYST, and the GNAT ( L-la in eukaryotes (Table 1)