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As, in a mouse model of gastric cancer, lipid aggregation in tumor-associated macrophages (TAMs) upregulated the expression of phosphoinositide 3-kinase (PI3K-) and promoted TAM polarization to the M2 phenotype

Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

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Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites
