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Hyperphosphorylation of tau, which results in the production of beta-amyloid plaques, occurs in AD as a result of extracellular beta-amyloid aggregation and tau aggregates

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Cells were pelleted and resuspended in 800 l PBS / containing 5 g px330 CRISPR DNA each and transferred into nucleofection cuvettes

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Afterwards it was synthesized in lab as a racemic mixture dl-3-n-butylphthalide and it became the first drug with independent intellectual property rights for use in cerebrovascular disease treatment in China [135]